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Before using Exubera, tell your doctor if you have kidney disease, liver disease, or lung disorders such as asthma or COPD (chronic obstructive pulmonary disease). Less common but more serious side effects can include serious bleeding, blood clots, very high blood pressure, severe diarrhea, holes forming in the intestines, and kidney, liver, or heart failure. Dexchlorpheniramine: (Moderate) Additive CNS depression is possible if chlorzoxazone is used concomitantly with other CNS depressants including sedating H1-blockers Zolmitriptan: (Minor) Retrospective data indicate that mean plasma concentrations of zolmitriptan were generally higher in females taking oral contraceptives (e.